Area-51 R2, AM5 motherboard swap

Unless you are absolutely stuck to the case and cannot live without it, I would simply purchase a new case.

@Vanadiel​ I really really like the case, so ill be putting an effort on keeping it xD

yes it is completely person choice.  I happen to agree with OP on the case choice, although I also see the point of Vanadiel on a whole new case or complete new model on a similar upgrade topic.

Re: Is the B650M-HDV/M.2 compatible with the I/O board?

yes it is, because the board has a standard USB 2.0 9 pin header.

@redxps630​ Thank you for the reply my friend!

Reckon ill still have to buy some extenders? Is there anything else I should worry about?

Which processor and graphics card are you using? What will be your cooling solutions? Are you staying with the OEM Alienware PSU?

You will need to do some case fabrication work for the ASRock I/O panel.

Asrock board seems to be microATX. The Dell front panel cable may be long enough so you would not need extender or new custom cable.

I installed old mATX XPS 8300 in R2 case as a test project. Cables fit.

@redxps630​ Wonderful! I might still need to buy one or two fan head extenders since the old x99 mobo has 4 fan headers on the top section of the board, while the new ASROCK has only 2.

@ProfessorW00d​ I'll be running the following specs:

• TUF GAMING Radeon™ RX 6800 XT OC Edition
• Amd Ryzen 5 7600
• Lexar Thor DDR5 32GB (2x16GB) 6000MHz CL32 1.35V
• COOLER MASTER G700 GOLD, 700W, 80 PLUS GOLD
• CoolerMaster 212 Black Edition CPU Air Cooler

I'm already running the 6800XT on my system and i am getting 34ºC idle and a max temp of 60-70 when gaming so i think ill be ok regarding cooling.

From what i could measure it seems the I/O panel has the same dimension as the original x99 mobo

@AwesomeFenix​   very nice . . . keep us posted on your project progress, with some photos!!